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NFL Week 17 Predictions and Best Bets

It is the penultimate weekend of the regular season, and our NFL Week 17 predictions are loaded with pivotal matchups for playoff seeding. This week also includes three games on Christmas and a doubleheader on Saturday before an action-packed Sunday.

I break down my NFL predictions in Week 17 below. Also, I highlight my favorite games of the weekend and discuss my best bets for Week 17.

NFL Week 17 Overview

BetOnline provided the following odds for my Week 17 NFL predictions.

• Dallas Cowboys -7.0 (-110) vs. Washington Commanders
• Detroit Lions -6.0 (-113) vs. Minnesota Vikings
• Denver Broncos -13.0 (-118) vs. Kansas City Chiefs
• Houston Texans vs. Los Angeles Chargers -2.0 (-109)
• Baltimore Ravens vs. Green Bay Packers -2.5 (-116)
• Arizona Cardinals vs. Cincinnati Bengals -7.0 (-115)
• Pittsburgh Steelers -3.0 (-120) vs. Cleveland Browns
• New Orleans Saints -2.5 (-116) vs. Tennessee Titans
• Jacksonville Jaguars -7.0 (+105) vs. Indianapolis Colts
• Tampa Bay Buccaneers -5.5 (-107) vs. Miami Dolphins
• New England Patriots -13.5 (-110) vs. New York Jets
• Seattle Seahawks -7.0 (-110) vs. Carolina Panthers
• New York Giants vs. Las Vegas Raiders -1.0 (-114)
• Philadelphia Eagles vs. Buffalo Bills -2.0 (-110)
• Chicago Bears vs. San Francisco 49ers -3.0 (-110)
• Los Angeles Rams -9.0 (+105) vs. Atlanta Falcons

Top NFL Week 17 Games to Watch

Here are my top games for Week 17 in the NFL.

• Detroit Lions -6.0 (-113) vs. Minnesota Vikings
• Houston Texans vs. Los Angeles Chargers -2.0 (-109)
• Baltimore Ravens vs. Green Bay Packers -2.5 (-116)
• New York Giants vs. Las Vegas Raiders -1.0 (-114)
• Philadelphia Eagles vs. Buffalo Bills -2.0 (-110)

Try our printable 2025-2026 NFL playoff bracket for more fun ways to bet on this season.

NFL Week 17 Predictions 2025

The top NFL betting sites are full of exciting odds for our NFL predictions for Week 17.

Detroit Lions -6.0 (-113) vs. Minnesota Vikings

Team	Point Spread	Moneyline	Total
Detroit Lions	-6.0 (-113)	-270	Over 44.5 (-110)
Minnesota Vikings	+6.0 (-107)	+222	Under 44.5 (-110)

Detroit suffered back-to-back losses for the first time since 2022. The Lions’ defeat last week put their chances of making the playoffs on life support.

Numbers speak for themselves pic.twitter.com/p0nAu40UwT

— Detroit Lions (@Lions) December 23, 2025

Despite losing three of their last four games, Jared Goff and the Lions are 6.0-point road favorites on Christmas against the Vikings in Minnesota. The Vikes have won back-to-back games but will be forced to start Max Brosmer this week as J.J. McCarthy’s hand injury will keep him from playing on a short week.

Minnesota beat Detroit in Week 9, but they will have a hard time repeating that upset if Brosmer is under center. The Lions are also more desperate now than they were eight weeks ago, and Detroit will pull out all the stops to keep its season alive.

Brosmer also had one of the worst debuts in NFL history when forced into the starting role against Seattle. With him starting this week, Detroit should win and cover against its divisional rivals.

Houston Texans vs. Los Angeles Chargers -2.0 (-109)

Team	Point Spread	Moneyline	Total
Houston Texans	+2.0 (-111)	+110	Over 39.5 (-105)
Los Angeles Chargers	-2.0 (-109)	-130	Under 39.5 (-115)

Houston and LA square off this week in a rematch of their playoff matchup from last season. Based on their current seeds, this could also be a preview of the playoffs this year.

Los Angeles is laying 2.0 points as the home favorite this week. However, the Chargers’ offensive line injuries will make slowing down the Texans’ defense almost impossible. If LA cannot keep Herbert upright, they have no chance of winning this game.

Herbert is no stranger to being under pressure. The Chargers’ QB has been sacked 49 times this season, the third-most of any QB.

Houston’s defense was the deciding factor when these teams met in the postseason. The Texans picked Herbert off four times. If they can repeat that performance this week, the Texans can pull off an upset in LA and improve their playoff seeding.

Baltimore Ravens vs. Green Bay Packers -2.5 (-116)

Team	Point Spread	Moneyline	Total
Baltimore Ravens	+2.5 (-104)	+132	Over 40.5 (-110)
Green Bay Packers	-2.5 (-116)	-152	Under 40.5 (-110)

Another great matchup on Saturday pits the Ravens (7-8) against the Packers (9-5-1). Both teams are reeling from costly losses after their QBs exited early with injuries.

Lamar Jackson left late in the first half with a back injury and did not return on SNF against the Patriots. Jordan Love, on the other hand, exited Saturday’s loss to the Bears in the mid-second quarter with a concussion.

Packers QBs Jordan Love (concussion) and Malik Willis (shoulder) are both dealing with injuries coming out of Saturday night's loss to the Bears. https://t.co/NZWuJcXNaW pic.twitter.com/mAYeiuZb0Q

— The Packers Wire (@ThePackersWire) December 22, 2025

With both starting QBs questionable for this game, each team’s playoff hopes could be in the hands of their backups. Green Bay is a 2.5-point home favorite for this cross-conference clash with major postseason implications.

Green Bay has the better defense, but it has not been as dominant since Micah Parsons’ season-ending ACL tear.

Jackson is also a better bet to start than Love, as the concussion protocol takes a long time to get through. Assuming Jackson pushes through and plays, I think the Ravens are a live underdog this week in Lambeau.

New York Giants vs. Las Vegas Raiders -1.0 (-114)

Team	Point Spread	Moneyline	Total
New York Giants	+1.0 (-106)	+100	Over 42.0 (-110)
Las Vegas Raiders	-1.0 (-114)	-120	Under 42.0 (-110)

A battle of two-win teams usually does not draw much attention this late in the season. However, this weekend’s matchup between the Giants (2-13) and the Raiders (2-13) is a rare exception.

New York currently has the number one pick in the 2026 Draft, and the Raiders are second. The winner of this game will lose their chance to have the top pick in April.

Both teams bring nine-game losing streaks into Sunday’s matchup. Las Vegas is a slight home favorite at -1.0 this weekend. New York is available as an even-money underdog on the moneyline.

Ashton Jeanty had a breakout game last week and could take over this game if given the chance. The Giants have the better QB, though, and Jaxson Dart could have a career day against a Raiders’ defense allowing 25.7 PPG.

Philadelphia Eagles vs. Buffalo Bills -2.0 (-110)

Team	Point Spread	Moneyline	Total
Philadelphia Eagles	+2.0 (-110)	+107	Over 43.5 (-110)
Buffalo Bills	-2.0 (-110)	-127	Under 43.5 (-110)

Sunday also features arguably the biggest matchup of the weekend, as the Eagles (10-5) visit Orchard Park to face the Bills (11-4). Buffalo is a 2.0-point home favorite in this potential Super Bowl 60 preview.

The Bills are 6-1 at home this season, are riding a four-game winning streak, and have a +90 point differential this season. Philly, on the other hand, is 5-3 on the road, has won back-to-back games, and posts a +60 point differential so far this year.

Saquon Barkley in his last 3 games:

– 332 yards
– 3 touchdowns
– 5.3 yards per carry

He’s back. pic.twitter.com/oIFesnUmAq

— Word On The Birds (@WordOnTheBirds) December 21, 2025

This game will be decided by two factors: Josh Allen’s health and the Bills’ run defense.

Allen hurt his ankle last week against the Browns. If he is limited in any way, then Buffalo’s offense could be in trouble.

The Bills’ run defense is already in trouble heading into this matchup. Buffalo has allowed the third-most rushing yards this season. They have also given up 24 rushing TDs, the most of any team in the NFL.

If Buffalo cannot stop Saquon Barkley, then the reigning Offensive Player of the Year could have his best game of the season. A big day from Barkley will be enough for the Eagles to win, especially if Allen is limited.

More NFL Week 17 Picks & Predictions

Matchup	Week 17 Predictions
Dallas Cowboys -7.0 (-110) vs. Washington Commanders	Dallas Cowboys -7.0 (-110)
Denver Broncos -13.0 (-118) vs. Kansas City Chiefs	Denver Broncos -13.0 (-118)
Arizona Cardinals vs. Cincinnati Bengals -7.0 (-115)	Arizona Cardinals +7.0 (-105)
Pittsburgh Steelers -3.0 (-120) vs. Cleveland Browns	Cleveland Browns (+160)
New Orleans Saints -2.5 (-116) vs. Tennessee Titans	New Orleans Saints -2.5 (-116)
Jacksonville Jaguars -7.0 (+105) vs. Indianapolis Colts	Jacksonville Jaguars -7.0 (+105)
Tampa Bay Buccaneers -5.5 (-107) vs. Miami Dolphins	Miami Dolphins +5.5 (-113)
New England Patriots -13.5 (-110) vs. New York Jets	New England Patriots -13.5 (-110)
Seattle Seahawks -7.0 (-110) vs. Carolina Panthers	Carolina Panthers +7.0 (-110)
Chicago Bears vs. San Francisco 49ers -3.0 (-110)	Chicago Bears +3.0 (-110)
Los Angeles Rams -9.0 (+105) vs. Atlanta Falcons	Atlanta Falcons +9.0 (-125)

Where to Bet on Your NFL Week 17 Predictions

BetOnline is the best place to bet on your NFL Week 17 predictions, including your Christmas Day picks. New members who use the code FREE250 can get a 50% match worth up to $250 in free bet funds with their first deposit.