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There are so many upsets and hat tricks during the NFL season that it can be difficult to predict who will hoist the Lombardi trophy in February.
But sportsbooks already have odds and lines available for Super Bowl winners, conference champions, and much more.
We’re going to throw in some of our thoughts and make some season-long predictions, as well as showcase our weekly 2025 NFL predictions.
2025 Weekly NFL Predictions
Each week, we’ll put out a new post with our thoughts on the next week of the season. These posts include our picks, NFL betting site recommendations, and more.
Week 6 (2025) – Betting Lines and NFL Predictions (Last Updated 10/8/2026)
Our Top Pick: Detroit Lions vs. Kansas City Chiefs (-2.5)
The Chiefs enter Sunday night as narrow home favorites, but the red-hot Lions look primed to keep rolling. Detroit has averaged nearly 35 points per game during its four-game winning streak, while Kansas City is coming off a short week after losing on Monday night. With the Lions firing on all cylinders offensively, there’s value on the underdog to stay hot in Arrowhead.
- Prediction: Detroit Lions +117
For a deeper look at the rest of the board and updated line movement, visit our full breakdown of this week’s NFL betting odds and predictions.
2025 NFL Futures and Outrights
While the odds for the Super Bowl Winner and other end-of-season titles are always shifting as team rankings change, we can still make a prediction on the winners for each category with current information.
Super Bowl Odds
Last week, our leading NFL expert, Shaun Stack, had the Buffalo Bills as his top pick to win the Super Bowl. They were 4-0 then, and are 4-1 now, but their odds are still quite good. Last week they were +400, this week they are +500.
The Bills are still the best-priced team in the league, next to the Lions at +700 and the Eagles at +750.
Check out our in-depth Super Bowl LX futures blog post for more picks and predictions.
Conference Winners
Here’s a look at the 2025 NFL conference winner odds from BetUS. Our team came up with a few predictions, including:
- Detroit Lions to Win the NFC
- Buffalo Bills to Win the AFC
NFC Conference Winner 2025-26
| Team | BetUS Odds | Previous Odds |
|---|---|---|
| Philadelphia Eagles | +400 | +300 |
| Detroit Lions | +375 | +400 |
| San Francisco 49ers | +850 | +750 |
| Washington Commanders | +1100 | +850 |
| Green Bay Packers | +450 | +900 |
| Los Angeles Rams | +850 | +1400 |
| Chicago Bears | +5000 | +2000 |
| Minnesota Vikings | +2800 | +1600 |
| Tampa Bay Buccaneers | +1000 | +1600 |
| Arizona Cardinals | +8000 | +3000 |
| Atlanta Falcons | +4000 | +2500 |
| Dallas Cowboys | +4000 | +2500 |
| Seattle Seahawks | +2000 | +3000 |
| Carolina Panthers | +20000 | +6000 |
| New Orleans Saints | +35000 | +8000 |
| New York Giants | +25000 | +10000 |
AFC Conference Winner 2025-26
| Team | BetUS Odds | Previous Odds |
|---|---|---|
| Baltimore Ravens | +800 | +350 |
| Kansas City Chiefs | +450 | +350 |
| Buffalo Bills | +250 | +375 |
| Cincinnati Bengals | +25000 | +800 |
| Houston Texans | +2000 | +1400 |
| Los Angeles Chargers | +800 | +1100 |
| Denver Broncos | +900 | +1400 |
| Miami Dolphins | +25000 | +2500 |
| Pittsburgh Steelers | +2000 | +2500 |
| Indianapolis Colts | +850 | +4000 |
| Jacksonville Jaguars | +1200 | +4000 |
| New York Jets | +50000 | +6000 |
| Las Vegas Raiders | +25000 | +6000 |
| New England Patriots | +2200 | +3000 |
| Cleveland Browns | +25000 | +8000 |
| Tennessee Titans | +50000 | +10000 |
Division Winners
Picking the Division winner is a little easier, with only 4 teams in each division. Most teams with an early season lead end up winning the division title. Here are some of our picks:
- Eagles to win NFC East (-200)
- Buccaneers to win NFC South (-425)
- Rams to win NFC West (+190)
- Lions to win NFC North (+100)
- Bills to win AFC East (-450)
- Colts to win AFC South (-115)
- Chargers to win AFC West (+170)
- Steelers to win AFC North (+100)
NFC East Winner 2025-26
| Team | BetUS Odds | Previous Odds |
|---|---|---|
| Philadelphia Eagles | -200 | -140 |
| Washington Commanders | +190 | +240 |
| Dallas Cowboys | +1000 | +750 |
| New York Giants | +12500 | +3300 |
NFC South Winner 2025-26
| Team | BetUS Odds | Previous Odds |
|---|---|---|
| Tampa Bay Buccaneers | -425 | +110 |
| Atlanta Falcons | +400 | +240 |
| Carolina Panthers | +1500 | +450 |
| New Orleans Saints | +3300 | +1200 |
NFC West Winner 2025-26
| Team | BetUS Odds | Previous Odds |
|---|---|---|
| San Francisco 49ers | -125 | +175 |
| Los Angeles Rams | +190 | +200 |
| Seattle Seahawks | +500 | +600 |
| Arizona Cardinals | +3000 | +600 |
NFC North Winner 2025-26
| Team | BetUS Odds | Previous Odds |
|---|---|---|
| Detroit Lions | Ev | +140 |
| Green Bay Packers | +115 | +280 |
| Minnesota Vikings | +1000 | +475 |
| Chicago Bears | +2200 | +500 |
AFC East Winner 2025-26
| Team | BetUS Odds | Previous Odds |
|---|---|---|
| Buffalo Bills | -450 | -230 |
| Miami Dolphins | +10000 | +650 |
| New England Patriots | +350 | +750 |
| New York Jets | +25000 | +1800 |
AFC North Winner 2025-26
| Team | BetUS Odds | Previous Odds |
|---|---|---|
| Baltimore Ravens | +105 | -135 |
| Cincinnati Bengals | +1600 | +230 |
| Pittsburgh Steelers | Ev | +600 |
| Cleveland Browns | +1800 | +3000 |
AFC South Winner 2025-26
| Team | BetUS Odds | Previous Odds |
|---|---|---|
| Houston Texans | +625 | +120 |
| Indianapolis Colts | -115 | +390 |
| Jacksonville Jaguars | +130 | +330 |
| Tennessee Titans | +25000 | +800 |
AFC West Winner 2025-26
| Team | BetUS Odds | Previous Odds |
|---|---|---|
| Kansas City Chiefs | +180 | -115 |
| Lost Angeles Chargers | +170 | +325 |
| Denver Broncos | +180 | +425 |
| Las Vegas Raiders | +8000 | +2000 |
Award Futures
Before the season even starts, you can bet on which players will walk away with end-of-the-year awards like MVP, Rookie of the Year, etc.
The MVP race is the most prominent, for obvious reasons, and we frequently cover it in our NFL MVP Odds and Predictions post.
But, other awards can be just as profitable. Here are some of our predictions:
- Abdul Carter to win Defensive Rookie of the Year (+150)
- Emeka Egbuka to win Offensive Rookie of the Year (+110)
- Shane Steichen to win NFL Coach of the Year (+325)
- Dak Prescott to win NFL Comeback Player of the Year (+250)
NFL Defensive Rookie of the Year Odds
| Player | BetUS Odds | Previous Odds |
|---|---|---|
| Abdul Carter | +150 | +200 |
| Jihaad Campbell | +250 | +350 |
| Carson Schwesinger | +500 | +1200 |
NFL Offensive Rookie of the Year Odds
| Player | BetUS Odds | Previous Odds |
|---|---|---|
| Ashton Jeanty | +400 | -120 |
| Emeka Egbuka | +110 | +500 |
| Jaxson Dart | +650 | +1000 |
NFL Coach of the Year Odds
| Player | BetUS Odds | Previous Odds |
|---|---|---|
| Liam Coen | +450 | +1200 |
| Shane Steichen | +325 | +2500 |
| Kyle Shanahan | +850 | +3000 |
NFL Comeback Player of the Year Odds
| Player | BetUS Odds | Previous Odds |
|---|---|---|
| Dak Prescott | +250 | +750 |
| Aidan Hutchinson | +275 | +300 |
| Christian McCaffrey | +200 | +300 |
How We Make NFL Picks
Every NFL pick we make is backed by research, data, and a clear understanding of how the game evolves week to week. Our process starts with analyzing recent injuries to key players, since even a single absence can drastically alter a team’s game plan or betting value. We also evaluate each team’s ability to move the ball—both through the air and on the ground—to determine whether their offense can sustain drives and convert in the red zone.
Defensive and offensive performance metrics play a major role, too. We look at yards allowed per play, third-down efficiency, turnover differential, and situational stats like red-zone defense to get a complete picture of each matchup. Finally, we monitor line movements from previous weeks to see how the betting market has reacted. Sharp money and public sentiment often reveal underlying trends that can give bettors an edge.
By combining these insights with advanced analytics and on-field context, we aim to provide picks that reflect both the numbers and the nuance of every NFL matchup.
Here’s Shaun Stack, one of our NFL experts, talking about how he picks games:
“I try to account for as many factors as possible, from usage rates and schemes to weather and a coach’s job security. Some schemes matchup better against others, while some teams and players are at a distinct advantage in cold or rainy weather. Coaches on the hot seat usually take bigger risks, too, including who they start and what plays they run.”
FAQs
What is closing line value (CLV) in NFL betting, and why does it matter?
Answer
Closing line value measures how your bet compares to the final odds before kickoff. If you bet the Chiefs -3 early in the week and the line closes at Chiefs -4.5, you’ve beat the closing line. Over time, consistently getting better numbers than the market indicates you’re finding value, even if individual bets lose.
Why are 3 and 7 key numbers in NFL point spreads?
Answer
NFL games often end with margins of 3 or 7 points because of field goals or touchdowns. That’s why a spread moving from +3 to +2.5 or from -7 to -7.5 is a major shift in expected outcome. Savvy bettors look for opportunities to get or avoid the “hook” (the half-point) on these numbers, especially when line shopping across sportsbooks.
What are lookahead lines?
Answer
Lookahead lines are early spreads and totals for next week’s games, posted before the current week’s slate is played. They’re often softer because sportsbooks limit action to avoid sharp exposure. If you can predict how a team’s performance or injury news will affect next week’s perception, you can grab a better number before the market adjusts.
What happens to NFL futures bets if a player doesn't complete the season?
Answer
Most sportsbooks grade futures “as action” unless the entire event is canceled. That means if you bet on a player to win MVP and they get hurt midseason, the bet still stands. That means you’ll lose unless the player still manages to win the award. Always read the sportsbook’s house rules, because terms can vary between sites for futures markets like MVP or Rookie of the Year.
Can you cash out an NFL futures bet midseason?
Answer
Yes, many sportsbooks now allow early cashouts on futures bets. The cashout value reflects the current odds and the book’s margin, so it’s usually less than the full expected value. Cashing out can make sense to lock in profit or cut losses, but long-term bettors often hold positions if they believe the market hasn’t fully corrected yet.
Summary
The 2025 NFL season is shaping up to be one of the most unpredictable in years, and the futures markets are already showing plenty of movement. From Super Bowl odds to conference winners, there’s no shortage of value if you’re watching line shifts closely and jumping early on the right teams. Whether it’s Detroit making noise in the NFC or Buffalo pushing for the top spot in the AFC, smart bettors know these midseason prices won’t last long.
Each week, we’ll keep tracking the biggest odds moves, injury updates, and betting trends that shape the board. Stay tuned to GamblingNerd for fresh analysis, updated futures picks, and expert predictions as we get closer to the playoffs.
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