• Boxing

Manny Pacquiao vs Mario Barrios Odds and Picks

One of the most legendary boxers of our lifetime returns this weekend in Barrios vs. Pacquiao. Boxing Hall of Famer Manny Pacquiao returns to professional competition after a four-year retirement. His opponent, Mario Barrios, is the reigning WBC welterweight champion.

Can Pacquiao win gold in his return, or should he have stayed retired? More importantly, what do the oddsmakers say about this upcoming fight? Keep reading for the latest Pacquiao vs. Barrios odds and my predictions for this matchup.

Pacquiao-Barrios Fight Details

Before breaking down the current Pacquiao vs Barrios odds from top boxing betting sites, here is everything you need to know about the fight itself.

• Pacquiao vs. Barrios date: July 19th, 2025
• Start time for Barrios vs. Pacquiao: 8 p.m. Eastern
• Barrios vs. Pacquiao location: MGM Grand Garden Arena, Las Vegas, Nevada
• How to watch Pacquiao vs. Barrios: Premier Boxing Championship on Prime PPV

Also, despite Pacquiao’s four-year absence, this is a title fight. If Pacquiao can defeat Barrios, he will be the new WBC welterweight champion.

Pacquiao vs. Barrios Odds

See the table below for the latest Pacquiao vs. Barrios odds, courtesy of BetUS.

Fighter	Moneyline Odds	Total Rounds
Manny Pacquiao	+210	Over 10.5 rounds (-120)
Mario Barrios	-260	Under 10.5 rounds (-110)

Barrios is a -260 favorite to retain his WBC welterweight championship against Pacquiao (+210). The oddsmakers also have the fight favored to go over 10.5 rounds (-120).

Read our free BetUS review to find out more about this highly-rated betting site.

Manny Pacquiao (+210)

After four years away from the sport, Manny Pacquiao (62-8-2) returns for a title fight. Before his retirement, Pacquiao’s recent fights included:

• UD loss to Yordenis Ugás on August 21st, 2021
• SD win over Keith Thurman on July 20th, 2019
• UD win over Adrien Broner on January 19th, 2019
• TKO win over Lucas Matthysse on July 15th, 2018
• UD loss to Jeff Horn on July 2nd, 2017

On one hand, Pacquiao has won three of his last four fights. However, due in part to his four-year retirement, the PacMan has not won a fight in nearly six years.

Pacquiao is also 46 years old, and despite his recent exhibition matches, ring rust could play a significant factor in Saturday’s fight. PacMan will be at a considerable size disadvantage as well. He is just 5’5 with a 67-inch reach, while Barrios is 6’0 with a 70-inch reach. 

Mario Barrios (-260)

Mario Barrios (29-2-1) defeated Yordenis Ugás for the WBC welterweight title on September 30th, 2023. He has defended the belt twice, including a UD win over Fabián Maidana in May 2024.

Barrios’s other title defense was a split decision draw against Abel Ramos. 

Before his move to welterweight, Barrios had a short reign as the WBA (regular) super lightweight champion. However, in his second title defense, Barrios suffered his first career loss and dropped the belt to Gervonta “Tank” Davis.

Barrios was born May 18th, 1995, nearly four months after Pacquiao made his professional debut.

In his career, Barrios has used his reach and an aggressive offensive to overwhelm opponents. However, that could cost him against Pacquiao, who is a master at countering his opponents. On the other hand, Barrios is bigger than any opponent PacMan has faced in his legendary career. 

Total Rounds

• Over 10.5 rounds (-120)
• Under 10.5 rounds (-110)

BetUS also has a market for the number of rounds the Pacquiao vs. Barrios fight lasts. The over/under for total rounds is set at 10.5, with the over listed as a -120 favorite. However, the under is a close second at -110.

Only one of Barrios’s last five fights has not gone the distance. Likewise, since 2013, only one of Pacquiao’s fights did not go the distance.

Pacquiao’s age and his time away from competition could impact his condition. Barrios also has 18 KO wins in his career and has the power to stop Pacquiao if he can land the right combination.

Pacquiao vs. Barrios Props

In addition to betting on the winner of the fight, secure sports betting sites have exciting Manny Pacquiao vs. Barrios prop wagers.

Fight Outcome – Method of Victory

One of the most popular props for Manny Pacquiao vs. Mario Barrios is this method of victory wager.

Method of Victory	Pacquiao Wins	Barrios Wins
KO, TKO, or DQ	+475	+130
Decision	+400	+200

A draw is also available in this market at +1300 odds.

The most likely outcome is for Barrios to win by KO, TKO, or DQ (+120). Barrios is also listed at 2-1 odds to win by decision.

Pacquiao’s best chance of winning is by decision (+400). PacMan is listed at +475 odds to win by KO, TKO, or DQ. Barrios has only been stopped once in his career, when Tank Davis knocked him out. His other career loss was a unanimous decision.

Conversely, PacMan has eight losses in his career, but five of them were by decision. The only fighters to beat Pacquiao without the judges’ help were Juan Manuel Márquez (2012), Medgoen Singsurat (1999), and Rustico Torrecampo (1996).

Final Round

Another great prop for Barrios vs. Pacquiao is this wager for the deciding round in the fight.

• Round 1-3 (+1400)
• Round 4-6 (+550)
• Round 7-9 (+350)
• Round 10-12 (+450)
• Fight goes the distance (-110)

The odds above apply only to the deciding round of the fight. You do not need to predict the winner.

Despite Barrios being favored to win by knockout, the option with the shortest odds in this market is for the fight to go the distance (-110). The next-best option is for the fight to end in rounds seven through nine (+350).

Pacquiao’s condition at age 46 is a major question mark in this fight. If he fades, that could be the open Barrios needs to end the fight early.

Exact Outcome

If you want a shot at bigger rewards, consider this prop on the exact outcome for Barrios-Pacquiao.

Winning Round	Pacquiao Wins	Barrios Wins
Round 1	+9900	+6600
Round 2	+9900	+4000
Round 3	+7900	+3300
Round 4	+6500	+2500
Round 5	+5000	+2000
Round 6	+5000	+1600
Round 7	+4000	+1400
Round 8	+4000	+1400
Round 9	+4000	+1400
Round 10	+4000	+1400
Round 11	+4900	+1600
Round 12	+5000	+2000
Decision Win	+400	+200
Draw	+1400	+1400

The favorite in this prop is a Barrios win via decision (+200). Pacquiao pulling off the upset by decision is a relatively close second at 4-1 odds.

There are several options tied at 14-1 odds, including a draw. A Barrios win in rounds 7, 8, 9, or 10 is also available at +1400 each. For comparison, other than a decision win, no option for a Pacquiao win is listed at shorter than 40-1 odds.

Choosing the right round to wager on is tricky. However, the potential payoffs can be huge if your prediction is correct. Also, you can bet on multiple options in this prop to increase your chances of winning.

Pacquiao vs. Barrios Predictions

The surprise return of Manny Pacquiao has created an exciting betting opportunity for boxing fans. Pacquiao will take on Mario Barrios for the WBC welterweight title.

Here are my predictions for Pacquiao-Barrios this weekend in Las Vegas.

• Mario Barrios wins (-260)
• Under 10.5 rounds (-110)
• Mario Barrios wins by KO, TKO, or DQ (+130)
• Fight ends in rounds 7-9 (+350)
• Mario Barrios wins in Round 9 (+1400)

No one can deny Pacquiao’s status as one of the best boxers of the last three decades. However, stepping into a title fight after four years away from professional competition would be hard enough if PacMan were not also in his mid-40s.

Pacquiao’s best chance to win is by surviving the storm and trying to counter Barrios’s aggressive strikes. However, I doubt that he will get the chance this weekend.

Barrios has a major reach advantage, and his power is unquestioned. I think he will not only win this weekend, but El Azteca will become just the fourth person to knock out Pacquiao. By the ninth round, Pacquiao will be worn down enough for Barrios to stop the boxing Hall of Famer.

Where to Bet on Barrios vs. Pacquiao

Barrios vs. Pacquiao is scheduled for this Saturday, July 19th, in Las Vegas. Read the guide above to see the latest odds for this WBC welterweight title fight.

You can bet on Pacquiao’s return fight today with an account at BetUS. New members can get a 125% match on their first three qualifying deposits. This exciting welcome promo is a great way to grow your bankroll for this weekend’s boxing events.