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NFL Playoffs Predictions and Props

Four exciting games are on deck this weekend for your NFL Divisional Round predictions. The eight remaining teams are all just three wins away from lifting the Lombardi Trophy.

With pressure at a season-high, betting on any game is a great way to make every matchup more exciting. I break down my NFL predictions for the Divisional Round, including my winner predictions and favorite playoff prop bets. 

NFL Divisional Round Overview

Here is the full NFL Divisional Round schedule, using odds provided by Bet105.

• Buffalo Bills vs. Denver Broncos -1.0 (-111)
• San Francisco 49ers vs. Seattle Seahawks -7.5 (+105)
• Houston Texans vs. New England Patriots -3.5 (+103)
• Los Angeles Rams -3.5 (-115) vs. Chicago Bears

Try our printable 2025-2026 NFL playoff bracket for more ways to wager on the postseason. You can also use Bet105’s playoff rebate bonus to get 25% back on your NFL losses this week, up to $250.

NFL Divisional Round Predictions

Keep reading for a closer look at the latest odds from top NFL betting sites for every NFL Divisional Round matchup.

Buffalo Bills vs. Denver Broncos -1.0 (-111)

Team	Point Spread	Moneyline	Total
Buffalo Bills	+1.0 (-101)	+106	Over 46.0 (-102)
Denver Broncos	-1.0 (-111)	-119	Under 46.0 (-112)

Bo Nix and the Broncos are -1.0-point home favorites in a playoff rematch against Josh Allen and the Bills. Buffalo demolished Denver in the second half of their Wild Card matchup last year, winning 31-7 in Orchard Park.

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The rematch is in Denver, and the Broncos only lost once all year at Mile High. Allen is also coming into this game with multiple injuries, including foot, knee, and hand issues.

Buffalo will be dead in the water if Allen cannot carry them to a win this weekend. However, with the advances in modern medicine, Allen should be as close to 100% as possible on Saturday. Assuming Buffalo can exploit similar holes in the Broncos’ defense as the Jaguars and Commanders did, the Bills can win.

San Francisco 49ers vs. Seattle Seahawks -7.5 (+105)

Team	Point Spread	Moneyline	Total
San Francisco 49ers	+7.5 (-118)	+278	Over 45.0 (-109)
Seattle Seahawks	-7.5 (+105)	-337	Under 45.0 (-105)

Seattle and San Francisco started and ended the regular season against each other. Now, the 49ers and Seahawks will square off for a third time to start the Divisional Round in the NFC.

The Seahawks are 7.5-point home favorites against their division rival. Part of the large spread is due to the 49ers’ mounting injuries. San Fran has battled through injuries all season, but last week’s season-ending injury to George Kittle (Achilles) could be the nail in their coffin.

On the bright side, the 49ers still have Christian McCaffrey. Also, Seattle’s QB Sam Darnold has struggled in big games throughout his career. Darnold was a late addition to the injury report with an oblique injury and could be limited on Saturday.

San Fran held Seattle to 13 points in both their matchups this season. With that in mind, I think the 49ers can cover the spread this weekend.

Houston Texans vs. New England Patriots -3.5 (+103)

Team	Point Spread	Moneyline	Total
Houston Texans	+3.5 (-115)	+156	Over 41.0 (+100)
New England Patriots	-3.5 (+103)	-179	Under 41.0 (-114)

Houston’s two defensive TDs helped the Texans rack up 23 points in the fourth quarter of their 30-6 win over the Steelers. The Texans’ defense needs another productive performance this week against the Patriots in Foxborough.

https://twitter.com/HoustonTexans/status/2011922877302427876

New England is laying 3.5 points as a home favorite on Sunday. The Texans are +156 moneyline underdogs for this game.

Despite an impressive final score, the Texans’ offense struggled in the Wild Card. C.J. Stroud fumbled five times and threw an interception. His play must improve significantly to have a chance at upsetting the Pats this weekend.

Drake Maye and the Pats’ offense will be a much tougher test for Houston. They will take advantage of every mistake Houston makes, allowing New England to win and cover as home favorites.

Los Angeles Rams -3.5 (-115) vs. Chicago Bears

Team	Point Spread	Moneyline	Total
Los Angeles Rams	-3.5 (-115)	-197	Over 47.5 (-115)
Chicago Bears	+3.5 (+102)	+172	Under 47.5 (+100)

The final game of the Divisional Round pits the Rams against the Bears at Soldier Field. Chicago is the only home underdog this week, getting 3.5 points against Matthew Stafford and company.

Los Angeles has a great front seven on defense, but the Rams’ secondary has been a liability at times. The Rams have allowed 53 passing plays of 20+ yards, tied for the 10th most in the league.

Stopping Caleb Williams and the Bears’ passing attack late in games has been nearly impossible this season. Williams and company are likely to be down early, but Chicago has made a habit of pulling off improbable comebacks.

Even if they do not pull off the upset, the Bears’ record of late-game comebacks makes them a great option to secure a backdoor cover on Sunday.

Best NFL Player Props for the Divisional Round

Top NFL betting sites offer excellent NFL player props for the Divisional Round, too. Here are my top player props for this weekend’s playoff matchups.

Divisional Game	NFL Player Prop	Prop Odds
Buffalo Bills vs. Denver Broncos	Dawson Knox anytime TD scorer	+432
San Francisco 49ers vs. Seattle Seahawks	Christian McCaffrey over 5.5 receptions	-151
Los Angeles Rams vs. Chicago Bears	Blake Corum over 10.5 rush attempts	+112

Dawson Knox Anytime TD Scorer (+432)

The lack of playmaking wideouts has been a major hangup for the Bills’ offense all season. Buffalo does not have great receivers, but it does have one of the best tight end rooms in the NFL.

Dalton Kincaid led the team in receiving TDs with five, but Knox tied for second with four. Knox was also third on the team in receiving yards.

Knox is listed at +432 to score a TD this weekend against Denver. The Broncos’ defense will focus on stopping the run while also shutting down Kincaid and Khalil Shakir. That will open the door for Knox to step up and find the endzone this weekend.

Christian McCaffrey Over 5.5 Receptions (-151)

The injury to Kittle was a major blow to the 49ers’ offense. Luckily for San Fran, Christian McCaffrey is still available for this weekend’s matchup against Seattle.

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CMC led the 49ers in rushing and receiving this season, racking up over 400 touches in the regular season. Including last week’s Wild Card win, the talented RB averaged 6.0 receptions per game in his 18 starts this season.

Oddsmakers have CMC listed at over/under 5.5 receptions on Saturday. With Kittle out, CMC will need to shoulder even more of the load against the Seahawks, and he will cover the over on this player prop.

Blake Corum Over 10.5 Rush Attempts (+112)

Rounding out my list of the best NFL prop bets for the Divisional Round is this bet for Rams’ RB Blake Corum to have over 10.5 rush attempts. The second-year RB has carved out a major role for himself in LA’s offense.

After getting just 58 rush attempts as a rookie, Corum averaged 8.5 rush APG in year two. He had 11+ carries in eight games this season, including last week’s win over the Panthers.

The forecast calls for frigid temperatures in Chicago for this Sunday’s game. Cold weather will significantly impact the passing game, forcing LA to rely more on its rushing attack against a porous Bears’ rush defense. That is good news for Corum, who should see at least a dozen rush attempts against Chicago on Sunday.

Where to Bet on NFL Divisional Round Picks and Props

Betting on your NFL Divisional Round predictions at Bet105 is the best way to enjoy this weekend’s playoff matchups. The site offers exciting and competitive odds for every game, including rewarding playoff props.

New members can get a $50 free bet with their first qualifying deposit. Betting on this weekend’s games will also make you eligible for up to $250 in free play funds with the site’s 25% rebate on losing bets in the NFL Divisional Round.