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NFL Week 10 Predictions and Best Bets

Our NFL Week 10 predictions are loaded with exciting divisional matchups. Six of the 14 games this week feature divisional opponents. The International Series also enters the home stretch with the Falcons and Colts squaring off in Germany.

This guide analyzes the latest odds for every game on this week’s schedule. I discuss the current betting lines and highlight my top NFL predictions in Week 10.

NFL Week 10 Overview

See the list below for the latest Week 10 betting lines, courtesy of BetOnline. 

• Las Vegas Raiders vs. Denver Broncos -9.0 (-110)
• Atlanta Falcons vs. Indianapolis Colts -6.0 (-110)
• New Orleans Saints vs. Carolina Panthers -5.5 (-110)
• New York Giants vs. Chicago Bears -3.5 (-110)
• Jacksonville Jaguars vs. Houston Texans -1.5 (-113)
• Buffalo Bills -9.5 (-111) vs. Miami Dolphins
• Baltimore Ravens -4.0 (-110) vs. Minnesota Vikings
• Cleveland Browns -2.5 (-115) vs. New York Jets
• New England Patriots vs. Tampa Bay Buccaneers -2.5 (-117)
• Arizona Cardinals vs. Seattle Seahawks -6.5 (-113)
• Los Angeles Rams -3.5 (-115) vs. San Francisco 49ers
• Detroit Lions -9.0 (-115) vs. Washington Commanders
• Pittsburgh Steelers vs. Los Angeles Chargers -2.5 (-125)
• Philadelphia Eagles vs. Green Bay Packers -2.5 (-110)

The four teams that one byes in Week 10 are Dallas, Cincinnati, Tennessee, and Kansas City.

Top NFL Week 10 Games to Watch

Here are my top five matchups to bet on in Week 10 at the best NFL betting sites.

• Baltimore Ravens -4.0 (-110) vs. Minnesota Vikings
• Cleveland Browns -2.5 (-115) vs. New York Jets
• New England Patriots vs. Tampa Bay Buccaneers -2.5 (-117)
• Los Angeles Rams -3.5 (-115) vs. San Francisco 49ers
• Philadelphia Eagles vs. Green Bay Packers -2.5 (-110)

NFL Week 10 Predictions 2025

Let’s take a deep dive into my NFL predictions for Week 10.

Baltimore Ravens -4.0 (-110) vs. Minnesota Vikings

Team	Point Spread	Moneyline	Total
Baltimore Ravens	-4.0 (-110)	-210	Over 48.5 (-110)
Minnesota Vikings	+4.0 (-110)	+180	Under 48.5 (-110)

Baltimore won back-to-back games for the first time this season and improved to 3-5 with their TNF win over the Dolphins. Minnesota (4-4) also won last week, securing a shocking upset victory over Detroit.

Despite the Vikings’ massive upset win last week, Minnesota is a 4.0-point underdog this week at home. Baltimore, which cannot afford another loss this season, is the -210 moneyline favorite.

Baltimore’s defense has looked better over the last two games, and the return of Lamar Jackson has improved the Ravens’ playoff chances. Minnesota’s defense, which blitzes more than any other team, will test the health of Jackson’s hamstring.

The question is whether Minnesota’s offense can repeat its performance from last week. McCarthy only completed 14 passes for 143 yards, but he racked up three total TDs in the win.

They may fall short of the outright upset, but Minnesota will cover the spread at home.

Cleveland Browns -2.5 (-115) vs. New York Jets

Team	Point Spread	Moneyline	Total
Cleveland Browns	-2.5 (-115)	-145	Over 37.5 (-110)
New York Jets	+2.5 (-105)	+125	Under 37.5 (-110)

Cleveland’s defense had six sacks against the Patriots in Week 8, but the Browns still lost 32-13. The Browns had a bye last week, giving them extra time to stew over their 2-6 record.

On the bright side, the Browns have a great shot to get their third win as they take on the 1-7 Jets this weekend. The Jets opened as favorites for this game. However, the NYJ traded away Sauce Gardener and Quinnen Williams, their two best defensive players.

After the trades, the lines moved in favor of the Browns, and Cleveland is now a 2.5-point favorite.

Cleveland is far from a good team, but the Jets were worse even before they tore down their defense. The Browns will win their first road game of the season, covering the 2.5 points at MetLife this Sunday.

New England Patriots vs. Tampa Bay Buccaneers -2.5 (-117)

Team	Point Spread	Moneyline	Total
New England Patriots	+2.5 (-103)	+130	Over 48.5 (-105)
Tampa Bay Buccaneers	-2.5 (-117)	-150	Under 48.5 (-115)

In one of the best matchups of the week, the Patriots (7-2) look to earn their seventh consecutive win as they take on the Buccaneers (6-2) in Tampa Bay. The Pats narrowly beat the Falcons last week, earning a 24-23 victory after Atlanta missed a PAT late in the game.

Tampa Bay, on the other hand, had a bye last week. The Bucs are laying 2.5 points at home for this matchup. Drake Maye and the Pats are +130 road underdogs on Sunday.

Maye has emerged as a dark horse MVP candidate in his sophomore season. He ranks top-five in total passing yards (2,285), yards per attempt (9.0), and passing TDs (17). However, he has also been sacked 34 times, second only to Cam Ward (38) for the most in the NFL.

Injuries threatened to derail the Bucs’ season, but Baker Mayfield and company battled through them. Now that they have had their bye to recover and prepare, the Bucs will be ready to end New England’s winning streak on Sunday.

Los Angeles Rams -3.5 (-115) vs. San Francisco 49ers

Team	Point Spread	Moneyline	Total
Los Angeles Rams	-3.5 (-115)	-195	Over 49.5 (-110)
San Francisco 49ers	+3.5 (-105)	+170	Under 49.5 (-110)

In one of the most consequential divisional matchups of the week, the Rams look to even the regular-season series with the 49ers. San Francisco (6-3) beat Los Angeles (6-2) with a field goal in overtime when these teams met on TNF in Week 5.

LA is a 3.5-point road favorite for the rematch this Sunday.

The Rams have not lost since that game, outscoring their opponents 86-20 over the last three weeks. LA has also won each of its last three games by at least two scores.

San Fran has been less successful, going just 2-2 over the last month. The 49ers have relied on backup Mac Jones as Brock Purdy continues to rehab from a toe injury. Jones, who beat the Rams in Week 5, could start again if Purdy misses another game.

Purdy is not the only injured player the 49ers need to worry about. San Fran’s defensive injuries will make it impossible to stop the Rams’ high-scoring offense, and LA will pick up the win this weekend.

Philadelphia Eagles vs. Green Bay Packers -2.5 (-110)

Team	Point Spread	Moneyline	Total
Philadelphia Eagles	+2.5 (-110)	+112	Over 45.0 (-110)
Green Bay Packers	-2.5 (-110)	-132	Under 45.0 (-110)

Rounding out my Week 10 NFL predictions is the Monday Night Football showdown between the Eagles and the Packers.

Green Bay lost at home last week to Carolina, falling to 5-2-1 on the season. Philadelphia had a bye in Week 9 and brings a two-game winning streak into this Wild Card rematch from last season.

The Packers are 2.5-point home favorites at Lambeau on MNF.

Philadelphia was one of the most active buyers at this year’s trade deadline. Among the players acquired by the Eagles in recent weeks are Jaelen Phillips, Jaire Alexander, and Michael Carter II.

Green Bay is no doubt desperate for a win after last week’s embarrassing loss. The Packers also have revenge on their minds after the Eagles ended their season last year. However, Green Bay’s offensive struggles make them a risky bet against a Philly team that was rounding into form ahead of its bye.

More NFL Week 10 Picks & Predictions

Matchup	Week 10 NFL Prediction
Las Vegas Raiders vs. Denver Broncos -9.0 (-110)	Las Vegas Raiders +9.0 (-110)
Atlanta Falcons vs. Indianapolis Colts -6.0 (-110)	Indianapolis Colts -6.0 (-110)
New Orleans Saints vs. Carolina Panthers -5.5 (-110)	Carolina Panthers -5.5 (-110)
New York Giants vs. Chicago Bears -3.5 (-110)	Chicago Bears -3.5 (-110)
Jacksonville Jaguars vs. Houston Texans -1.5 (-113)	Jacksonville Jaguars (+105)
Buffalo Bills -9.5 (-111) vs. Miami Dolphins	Miami Dolphins +9.5 (-109)
Arizona Cardinals vs. Seattle Seahawks -6.5 (-113)	Seattle Seahawks -6.5 (-113)
Detroit Lions -9.0 (-115) vs. Washington Commanders	Detroit Lions -9.0 (-115)
Pittsburgh Steelers vs. Los Angeles Chargers -2.5 (-125)	Los Angeles Chargers (-148)

Where to Bet on Your NFL Week 10 Predictions

You can wager on your Week 10 NFL predictions today at BetOnline. It provides competitive betting lines for every game of the NFL season. There are thrilling bonus options, too, such as the $250 in free bets available to new members who use the code FREE250 when making their first deposits.