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NFL Week 13 Odds and Predictions

Betting on your NFL Week 13 predictions is the best way to capitalize on an exciting 16-game slate of holiday football. Every team is in action this week, so there are plenty of thrilling betting lines to wager on. 

Continue reading to see my NFL predictions in Week 13. I highlight the top matchups for this weekend and break down my best bets.

NFL Week 13 Overview

Here are the latest NFL Week 13 odds, courtesy of BetOnline.  

• Green Bay Packers vs. Detroit Lions -2.5 (-115)
• Kansas City Chiefs -3.5 (+105) vs. Dallas Cowboys
• Cincinnati Bengals vs. Baltimore Ravens -6.5 (-120)
• Chicago Bears vs. Philadelphia Eagles -7.0 (-105)
• Los Angeles Rams -10.5 (-109) vs. Carolina Panthers
• San Francisco 49ers -5.0 (-110) vs. Cleveland Browns
• Houston Texans vs. Indianapolis Colts -4.5 (-113)
• New Orleans Saints vs. Miami Dolphins -6.0 (-108)
• Atlanta Falcons -2.5 (-110) vs. New York Jets
• Arizona Cardinals vs. Tampa Bay Buccaneers -3.0 (-114)
• Jacksonville Jaguars -6.5 (-112) vs. Tennessee Titans
• Minnesota Vikings vs. Seattle Seahawks -10.0 (-115)
• Las Vegas Raiders vs. Los Angeles Chargers -9.5 (-110)
• Buffalo Bills -3.5 (-115) vs. Pittsburgh Steelers
• Denver Broncos -6.5 (-108) vs. Washington Commanders
• New York Giants vs. New England Patriots -7.5 (-105)

Top NFL Week 13 Games to Watch

Here are my top matchups of Week 13. 

• Chicago Bears vs. Philadelphia Eagles -7.0 (-105)
• Houston Texans vs. Indianapolis Colts -4.5 (-110)
• Arizona Cardinals vs. Tampa Bay Buccaneers -3.0 (-110)
• Buffalo Bills -3.5 (-115) vs. Pittsburgh Steelers
• Denver Broncos -6.5 (-107) vs. Washington Commanders

For more NFL week 13 picks, check out our Thanksgiving Day game predictions. 

NFL Week 13 Predictions 2025

Let’s take a closer look at my best bets for Week 13 in the NFL. 

Chicago Bears vs. Philadelphia Eagles -7.0 (-105)

Team	Point Spread	Moneyline	Total
Chicago Bears	+7.0 (-115)	+254	Over 44.5 (-110)
Philadelphia Eagles	-7.0 (-105)	-312	Under 44.5 (-110)

The Bears and Eagles face off in this year’s Black Friday game. With both teams at 8-3, the winner of this game will have a major tiebreaker in the playoff seeding. 

Philly allowed 24 unanswered points after leading 21-0 in their loss last week. Despite their collapse against Dallas, the Eagles are 7.0-point home favorites against Chicago at the top NFL betting sites in this matchup of NFC division leaders. 

The Eagles’ offensive issues are nothing new, but they have typically found a way to overcome them. Philadelphia’s defense has carried the team at times, and they will need to step up this week against the Bears. 

Chicago is averaging over 30 PPG during its four-game winning streak. However, the Eagles’ defense will be a significant step up in competition compared to the teams the Bears have played over the last month. The increase in difficulty will be too much for Chicago to overcome, but the Bears can cover the spread on Friday. 

Houston Texans vs. Indianapolis Colts -4.5 (-113)

Team	Point Spread	Moneyline	Total
Houston Texans	+4.5 (-107)	+189	Over 44.0 (-110)
Indianapolis Colts	-4.5 (-113)	-225	Under 44.0 (-110)

Davis Mills led the Texans to three straight wins while C.J. Stroud recovered from a concussion. Stroud is expected to return to the lineup this week against the AFC South-leading Colts. 

Indianapolis lost last week in Kansas City, falling to 2-3 on the road. The Colts are at home this week and are laying 4.5 points against their divisional rivals. Houston is a +189 moneyline underdog in this AFC South matchup. 

Daniel Jones has struggled when teams shut down the run and force the journeyman QB to pass. Such was the case last week, when Jones and company gained just 131 yards after halftime in their OT loss, including four straight three-and-outs. 

Houston’s defense is even better than KC’s and is coming off an eight-sack performance against the Bills. The Texans’ defense will follow the blueprint laid out by the Chiefs and the Steelers to pull off the upset win over the Colts this week. 

Arizona Cardinals vs. Tampa Bay Buccaneers -3.0 (-114)

Team	Point Spread	Moneyline	Total
Arizona Cardinals	+3.0 (-106)	+140	Over 44.5 (-110)
Tampa Bay Buccaneers	-3.0 (-114)	-160	Under 44.5 (-110)

Next on my list of Week 13 NFL predictions is an NFC matchup between the Cardinals (3-8) and the Buccaneers (6-5). Tampa Bay holds a slim lead in the NFC South, but it is in danger of losing the divisional race after dropping four of its last five games. 

Arizona is all but eliminated from the playoffs, but that has not stopped the Cards from playing spoiler. They beat Dallas in Week 9, and Jacoby Brissett has thrown for at least 250 yards in each of his six starts this season. 

Tampa Bay’s poor injury luck is a major reason they have struggled as of late. The Bucs should get Bucky Irving back this week, but starting QB Baker Mayfield is questionable with a sprained left shoulder. 

Injuries have also ravaged their defense. Tampa Bay has allowed over 330 total yards of offense in six of its last seven games. That trend is likely to continue against an aggressive Cardinals’ passing offense, and I like Arizona as a live underdog in this game. 

Buffalo Bills -3.5 (-115) vs. Pittsburgh Steelers

Team	Point Spread	Moneyline	Total
Buffalo Bills	-3.5 (-115)	-200	Over 47.5 (-110)
Pittsburgh Steelers	+3.5 (-105)	+174	Under 47.5 (-110)

Buffalo (7-4) and Pittsburgh (6-5) are two of the most desperate playoff hopefuls in the AFC. The Bills need several miracles to catch the Patriots (10-2) in the AFC East. Pittsburgh, on the other hand, is a half-game behind the Ravens for the AFC North title after leading the division for the first 12 weeks. 

Both teams have struggled to string together wins lately, with Buffalo and Pittsburgh each dropping four of their last seven games. The Bills are 3.5-point road favorites this Sunday in Pittsburgh. 

The Steelers have not much well this season. They allow the fifth-most total yards (364.5 YPG), including over 250 YPG through the air. On offense, Pittsburgh musters fewer than 300 YPG, ranking near the bottom in passing and rushing YPG this year. 

Buffalo’s rushing defense is terrible, giving up nearly 150 YPG, but the Bills at least run the ball well themselves. They gain over 147 YPG on the ground, the most in the NFL. Their strong rushing attack should be all the Bills need to take down a struggling Steelers team that has issues across the board on both sides of the line of scrimmage. 

Denver Broncos -6.5 (-108) vs. Washington Commanders

Team	Point Spread	Moneyline	Total
Denver Broncos	-6.5 (-108)	-310	Over 43.5 (-110)
Washington Commanders	+6.5 (-112)	+252	Under 43.5 (-110)

The final game on my NFL predictions for Week 13 is the Sunday Night Football matchup between the Broncos and the Commanders. A win this week will move Denver one step closer to its first AFC West title since Peyton Manning retired. 

Denver is a 6.5-point road favorite against Washington on SNF. The Commanders are likely to be without Jayden Daniels, as the reigning Rookie of the Year continues to recover from a dislocated left elbow. 

Whoever is under center for Washington is in for a long night. Denver leads the NFL with 49 sacks, and the Broncos had a bye to prepare for this game. The bye also gave Patrick Surtain II enough time to recover from a pectoral injury that has kept him out since Week 8. 

Surtain’s return is huge for an already dominant Broncos’ defense. Denver should win this prime-time matchup in impressive fashion, getting its 10th win of the year and covering the spread. 

More NFL Week 13 Picks & Predictions

Matchup	Week 13 NFL Prediction
Green Bay Packers vs. Detroit Lions -2.5 (-115)	Green Bay Packers (+130)
Kansas City Chiefs -3.5 (+105) vs. Dallas Cowboys	Kansas City Chiefs (-175)
Cincinnati Bengals vs. Baltimore Ravens -6.5 (-120)	Baltimore Ravens -6.5 (-120)
Los Angeles Rams -10.5 (-109) vs. Carolina Panthers	Los Angeles Rams -10.5 (-109)
San Francisco 49ers -5.0 (-110) vs. Cleveland Browns	Cleveland Browns +5.0 (-110)
New Orleans Saints vs. Miami Dolphins -6.0 (-108)	Miami Dolphins -6.0 (-108)
Atlanta Falcons -2.5 (-110) vs. New York Jets	Atlanta Falcons -2.5 (-110)
Jacksonville Jaguars -6.5 (-112) vs. Tennessee Titans	Jacksonville Jaguars (-310)
Minnesota Vikings vs. Seattle Seahawks -10.0 (-115)	Minnesota Vikings +10.0 (-105)
Las Vegas Raiders vs. Los Angeles Chargers -9.5 (-110)	Las Vegas Raiders +9.5 (-110)
New York Giants vs. New England Patriots -7.5 (-105)	New England Patriots -7.5 (-105)

Where to Bet on Your NFL Week 13 Predictions

BetOnline is an excellent option for betting on your NFL Week 13 predictions. It offers competitive lines for every game and exciting betting tools, including a top-of-the-line pro builder. New members can also get $250 in free bets for this week’s games when they use the code FREE250 with their first qualifying deposit.