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NFL Week 18 Predictions and Best Bets

Betting on your NFL Week 18 predictions is the perfect way to ring in the new year. The final week of the season includes 16 divisional matchups, many of which can shake up the playoff picture.

Continue reading to see the latest odds and my top NFL predictions in Week 18. I break down the best games this week and give my best bets for the final week of the regular season.

NFL Week 18 Overview

BetOnline provided the following odds for our Week 18 NFL predictions.

• Carolina Panthers vs. Tampa Bay Buccaneers -2.5 (-124)
• Seattle Seahawks -1.5 (-110) vs. San Francisco 49ers
• New Orleans Saints vs. Atlanta Falcons -3.0 (-118)
• Cleveland Browns vs. Cincinnati Bengals -7.5 (-112)
• Green Bay Packers vs. Minnesota Vikings -6.5 (-110)
• Dallas Cowboys -3.5 (-110) vs. New York Giants
• Tennessee Titans vs. Jacksonville Jaguars -13.0 (-108)
• Indianapolis Colts vs. Houston Texans -10.0 (-120)
• New York Jets vs. Buffalo Bills -7.0 (-110)
• Arizona Cardinals vs. Los Angeles Rams -7.0 (-120)
• Detroit Lions vs. Chicago Bears -3.0 (-105)
• Los Angeles Chargers vs. Denver Broncos -12.5 (-110)
• Kansas City Chiefs -5.0 (-110) vs. Las Vegas Raiders
• Miami Dolphins vs. New England Patriots -11.0 (+100)
• Washington Commanders vs. Philadelphia Eagles -3.5 (-107)
• Baltimore Ravens -3.5 (-102) vs. Pittsburgh Steelers

Top NFL Week 18 Games to Watch

Here are the best games in Week 18 for fans and bettors.

• Carolina Panthers vs. Tampa Bay Buccaneers -2.5 (-124)
• Seattle Seahawks -1.5 (-110) vs. San Francisco 49ers
• Tennessee Titans vs. Jacksonville Jaguars -13.0 (-108)
• Los Angeles Chargers vs. Denver Broncos -12.5 (-110)
• Baltimore Ravens -3.5 (-102) vs. Pittsburgh Steelers

Check out this printable 2025-2026 NFL playoff bracket for more ways to bet on the upcoming postseason.

NFL Week 18 Predictions 2025

Continue reading for a closer look at my favorite Week 18 games to bet on at the top NFL betting sites.

Carolina Panthers vs. Tampa Bay Buccaneers -2.5 (-124)

Team	Point Spread	Moneyline	Total
Carolina Panthers	+2.5 (+104)	+130	Over 44.0 (-107)
Tampa Bay Buccaneers	-2.5 (-124)	-150	Under 44.0 (-113)

The Panthers and Buccaneers will face off for the second time in the last three weeks. This time around, the NFC South title is on the line.

Carolina faces a classic win-and-in situation. Tampa Bay, on the other hand, must win and have the Falcons lose to secure the divisional title. If Atlanta wins, then the Panthers will win the NFC South.

This means something to us! pic.twitter.com/xAHsLa5ph7

— Carolina Panthers (@Panthers) December 31, 2025

Baker Mayfield and the Bucs are 2.5-point home favorites in this matchup. They were favored in Week 16, too, but lost 23-20 on the road in Charlotte.

Bryce Young had two clutch passing TDs to lead the Panthers to the upset win. The Bucs have one of the worst passing defenses in the league, allowing 236.4 passing YPG and giving up 28 passing TDs. If Young can repeat his performance from Week 16, he will lead Carolina to another upset win over the Bucs this week.

Seattle Seahawks -1.5 (-110) vs. San Francisco 49ers

Team	Point Spread	Moneyline	Total
Seattle Seahawks	-1.5 (-110)	-125	Over 47.0 (-112)
San Francisco 49ers	+1.5 (-110)	+105	Under 47.0 (-108)

Seattle and San Francisco will also square off this week with a division title on the line. The winner of this game will clinch the NFC West and secure the number one overall seed in the conference.

The 49ers are at home, and they beat the Seahawks in Seattle to open the season. Despite that, San Fran is a 1.5-point underdog on Saturday.

Seattle has one of the league’s best offenses, racking up over 350 YPG this season. Their 29.4 PPG is second only to the Rams (30.1) this season. The Seahawks defense has also been excellent, allowing fewer than 293 total YPG and holding opponents to 18.2 PPG, the second-fewest in the NFL.

San Fran’s injury-riddled defense has not been nearly as stout, allowing nearly 340 YPG. Their offense has also been one-dimensional at times, running through Christian McCaffrey more often than not.

Seattle is better on both sides of the ball. Assuming the moment is not too big for Sam Darnold, the Seahawks will win and clinch the division.

Tennessee Titans vs. Jacksonville Jaguars -13.0 (-108)

Team	Point Spread	Moneyline	Total
Tennessee Titans	+13.0 (-112)	+534	Over 47.5 (-115)
Jacksonville Jaguars	-13.0 (-108)	-750	Under 47.5 (-105)

Jacksonville is one win away from ending the Texans’ reign atop the AFC South. If the Jaguars win this week, they will clinch the South and home-field advantage in the Wild Card round.

The good news for Jags fans is that Jacksonville faces Tennessee (3-13) this week. Jacksonville beat the Titans 25-3 in their Week 13 matchup.

The first Titans rookie since 2010 to be named a Pro Bowl starter @chimdk11 ⭐️ pic.twitter.com/73Atp1sG37

— Tennessee Titans (@Titans) December 23, 2025

With that in mind, it is no surprise that the Jaguars are laying 13.0 points as a home favorite in the rematch this weekend.

The Titans have been one of the worst teams in the league this season, ranking near the bottom in every offensive and defensive category. However, Tennessee has been more competitive lately, winning two of its last four games.

Jacksonville has been rolling lately, and they have major playoff aspirations. It is easy to overlook a 3-13 team, creating a classic trap game situation for the Jaguars this week. Jacksonville should win, but Tennessee will keep the game within 13.0 points.

Los Angeles Chargers vs. Denver Broncos -12.5 (-110)

Team	Point Spread	Moneyline	Total
Los Angeles Chargers	+12.5 (-110)	+561	Over 37.5 (-110)
Denver Broncos	-12.5 (-110)	-800	Under 37.5 (-110)

Denver is also a heavy favorite this weekend, laying 12.5 points against the visiting Chargers. Los Angeles has won three straight games against Denver. However, the Chargers announced earlier this week that Justin Herbert will not play this week.

Even before the announcement, the Chargers were a touchdown underdog. The Broncos have one of the best defenses in the league, including the most sacks (64) in the NFL.

Denver has a lot to play for this week, too. If the Broncos win, they clinch the top seed in the AFC and guarantee themselves a bye in the first round. It would also give Denver home-field advantage throughout the playoffs, and Mile High is one of the league’s toughest places to play.

With so much on the line against a backup QB, the Broncos should roll to an easy win in this game. Denver covers and builds momentum before the playoffs.

Baltimore Ravens -3.5 (-102) vs. Pittsburgh Steelers

Team	Point Spread	Moneyline	Total
Baltimore Ravens	-3.5 (-102)	-190	Over 40.5 (-115)
Pittsburgh Steelers	+3.5 (-118)	+165	Under 40.5 (-105)

Rounding out my NFL predictions for Week 18 is, fittingly, the regular season finale. Baltimore and Pittsburgh face off on Sunday Night Football in the final game of the regular season. The Steelers could have locked up the division last week, but they came up short, losing 13-6 against Cleveland.

Now, the Ravens and the Steelers will face off for the AFC North title. The loser will be out of the playoffs, and the losing coach could be out of a job.

Ravens QB Lamar Jackson (back) is practicing for a second straight day.

He was a full participant Wednesday.

It looks like Jackson will be ready to start Sunday’s AFC North title game at the Steelers.

— Jamison Hensley (@jamisonhensley) January 1, 2026

Baltimore lost to Pittsburgh in Week 14, but the Ravens are 3.5-point road favorites this time around. The line for this game has shifted more in the Ravens’ favor as it has become increasingly likely that Lamar Jackson will return this week.

Even without Jackson, the Ravens would rightfully be favored in this game. Pittsburgh’s offense is without three of its top five receiving options, including DK Metcalf (SUS) and Darnell Washington (broken arm).

The Steelers could not move the ball last week, and it should be much of the same this week. Baltimore, conversely, has leaned heavily on Derrick Henry. Baltimore will win after another huge performance from King Henry.

More NFL Week 18 Picks & Predictions

Matchup	Week 18 NFL Prediction
New Orleans Saints vs. Atlanta Falcons -3.0 (-118)	New Orleans Saints +3.0 (-102)
Cleveland Browns vs. Cincinnati Bengals -7.5 (-112)	Cleveland Browns +7.5 (-108)
Green Bay Packers vs. Minnesota Vikings -6.5 (-110)	Minnesota Vikings -6.5 (-110)
Dallas Cowboys -3.5 (-110) vs. New York Giants	Dallas Cowboys -3.5 (-110)
Indianapolis Colts vs. Houston Texans -10.0 (-120)	Houston Texans -10.0 (-120)
New York Jets vs. Buffalo Bills -7.0 (-110)	New York Jets +7.0 (-110)
Arizona Cardinals vs. Los Angeles Rams -7.0 (-120)	Arizona Cardinals +7.0 (+100)
Detroit Lions vs. Chicago Bears -3.0 (-105)	Detroit Lions +3.0 (-115)
Kansas City Chiefs -5.0 (-110) vs. Las Vegas Raiders	Kansas City Chiefs -5.0 (-110)
Miami Dolphins vs. New England Patriots -11.0 (+100)	New England Patriots -11.0 (+100)
Washington Commanders vs. Philadelphia Eagles -3.5 (-107)	Philadelphia Eagles -3.5 (-107)

Where to Bet on Your NFL Week 18 Predictions

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